Which cells in the male respond to FSH to stimulate gametogenesis and gonadal growth?

• A. Leydig cells
• B. Ovarian granulosa cells
• C. Adrenal cortex cells
• D. Sertoli cells

Answer: (D)

FSH acts directly on Sertoli cells in the seminiferous tubules. These cells have FSH receptors and, when stimulated, create a supportive environment for developing germ cells by providing nutrients, growth factors, and androgen-binding protein to keep testosterone high in the tubules. This direct action of FSH on Sertoli cells drives germ cell proliferation and maturation—gametogenesis—and supports overall testicular growth. Leydig cells, in contrast, respond mainly to LH to produce testosterone, which then aids Sertoli cell function but is not driven by FSH itself. The other cell types listed aren’t involved in FSH-driven male gametogenesis.